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| Awards
presented at the 10th World Congress on Endometriosis,
11 - 14 March 2008 |
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| Rodolphe
Maheux Award for the best presentation by a clinician
under the age of 40:
Drs Joas Dias and Sergio Podgaec
for their paper on "Time
elapsed between the onset of symptoms and the
diagnosis of deply infiltrating endometriosis",
which was also selected
as one of the key abstracts for the clinical plenary
session on "Diagnosis of endometriosis".
They demonstrated that patients with deep endometriosis
affecting the rectum, bladder or ureter have symptoms
for longer until they have a diagnosis and are
treated, than those women, who do not have these
types of lesions. 
read
more
Nine additional
prizes were awarded and funded by the Australian
Gynaecological Endoscopy Society (AGES). There
were three prizes awarded each day for the best
clinical free communication, the best scientific
free communication, and the best poster. |
AGES President Professor Alan Lam
presents Professor David Adamson
with the award
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Best clinical free communications
"Pre-operative histological
diagnosis of intestinal endometriosis achieved
by FNA during intestinal endosonography"
by Lucio Rossini et al, in which the
authors demonstrated that this is feasible with
high accuracy and can help to decide whether or
not to have an intestinal resection surgical approach
in cases of intestinal endometriosis.
"The MDOT study: menstrual
disorders of teenagers" by Melissa Parker
and Anne Sneddon, in which the authors demonstrated
how the MDOT questionnaire has helped to establish
a clearer picture of typical menstruation in the
study sample of 16-18 year old women attending
senior high school, where 25% experienced significant
menstrual disturbance, resulting in absence from
school.
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"Endometriosis
Fertility Index (EFI): the new, validated endometriosis
staging system" by David Adamson et al.
The authors had utilised data collected over two
decades to develop the EFI, which is a simple,
robust and validated clinical tool that predicts
non-IVF pregnancy rates following surgical staging
of endometriosis. The tool can therefore be used
to develop effective treatment plans. |
Best scientific free communications
"Oestrogen has differential
effects on VEGF-a isoform and receptor mRNA
expression in different cellular compartments
of the mouse uterus" by Jane Girling et
al, in which the authors demonstrated that
down-regulation of VEGF-a and its receptors
within the endometrial stroma identifies a potential
mechanism of the anti-angiogenic effects observed
in response to oestrogen. The authors have yet
to elucidate how oestrogen interacts with VEGF-a
to control the pro-angiogenic effects within
the endometrium, but were able to illustrate
how these results show the differential effects
of oestrogen on VEGF-a isoform and receptor
expression within the different cellular compartments
of the uterus.
"MicroRNA expression
in endometriosis" by Maria Ohlsson-Teague
et al, in which the authors demonstrated,
for the first time, significant differential
expression of microRNAs in endometriotic tissues
when compared to paired eutopic endometrium.
These non-coding RNAs are likely to contribute
to the pathophysiology of endometriotic lesion
development and could be a target for pharmacological
intervention in endometriosis.
"The role of the
EP2 receptor in the growth of ectopic lesions
in a mouse model of endometriosis" by Nick
Pullenet al, in which the authors concluded
that ectopic lesion growth appears to be dependent
on endometrial EP2-r expression, as donor EP2-r
KO lesions failed to grow in wild type mice,
in contrast to wild type tissue in EP2-r KO
animals. The effect of loss of EP2-r expression
on lesion growth was greater than that observed
with loss of COX-2, suggesting some redundancy
by COX-1 may compensate for the loss of COX-2
in lesion growth. According the the authors,
these data support the notion of specific blockade
of the EP2-r in the treatment of endometriosis.
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Best posters
"Structual changes during
menstrual shedding and repair" by Ray Garry
et al, in which the authors explained
that endometrial shedding and repair are focal
processes controlled in both vertical and horizontal
axes by differences in stromal cell make-up. The
authors demonstrated that the areas that are shed
are dominated by the presence of uNK cells that
are potentially highly destructive. In contrast,
areas that are not shed and are destined to regenerate,
have a stromal cell milieu that is dominated by
cells that expreses the CD34+ antigen, which is
known to be expressed in hematopoietic stem cells
and endothelial progenitor cells that contribute
to new vessel formation in the endometrium and
many other sites of injury.
"Absence of aromatase expression
in human peritoneal, ovarian and rectovaginal
endometriosis lesions" by Sebastian Colette
et al, in which the authors found no
aromatase expression in glands or stroma in the
three types of endometrioc lesions (peritoneal,
ovarian, and rectovaginal) nor in the corresponding
endometrium.
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Professor Ray Garry receives
the award from AGES president
Professor Alan Lam |
"Altered cell cycle control in endometrial
cultures from patients with endometriosis carrying
the PROGINS allele: evidences for impaired progesterone
action in endometriosis" by Paulo D'Amora
et al, in which the authors' data support
the hypothesis of an existing progesterone resistance
in endometriosis leading to disrupted cell cycle
control in cells harbouring the PROGINS (e-PRG)
polymorphism.
Photos
courtesey of Michael McEvoy
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Highlights
from WCE2008
Scientific summaries
from WCE2008
Next
World Congress on Endometriosis
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| The World Endometriosis Society |
The World
Endometriosis Society (WES) was founded in 1998
to promote the exchange of clinical experience,
scientific thought, and investigation among gynaecologists,
endocrinologists, scientists, biologists and other
qualified individuals interested in advancing
the field of endometriosis.
The WES is
a scientific Society with no link to the industry.
We fund our work from our membership dues and
from a share of the inscriptions from the World
Congresses on Endometriosis.
Join
the World Endometriosis Society
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